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I apologize in advance for the length of this post, but much of the material in it isn’t mine – it’s Anthony Colpo’s. Why don’t I simply link to the material instead of reprinting it? Because Anthony changes or removes his material when it proves to be an embarrassment to him. So I want you to see it the way it is as of today when I wrote this post.

For those of you unaware of the tempest in a teapot drama that has been going on for the past month or so, here’s the story.

About two months ago I wrote a post describing the Ancel Keys starvation studies of the 1940s and compared the data from these studies with those published by John Yudkin about 25 years later. I selected the Yudkin study because the subjects switching to low-carb diets spontaneously dropped their caloric intake to 1560 kcal, which was almost exactly the same as the 1570 kcal the Keys subjects consumed. I wrote then that I wasn’t

…truly comparing apples to apples with these studies, but they do confirm Yudkin’s 15 years of experience before he wrote his paper and they confirm my 20 plus years of experience taking care of patients on low-carb diets. I’ve had many, many patients who have stayed on low-carb diets for much, much longer than the men in Keys’ experiment stayed on their diets of roughly the same number of calories. Most of the papers in the medical literature on low-carb diets show a spontaneous drop in caloric intake that’s about what Yudkin documented when people switch over to low-carb diets. It stands to reason that if someone had replicated Keys’ experiment using the same number of calories, but with much more fat and a lot less carbohydrate, that the outcome would have been much different.

When I wrote those words it was at the end of a long post and I was ready to be done with it. I could have probably said what I meant a little better. If anyone wants a more comprehensive explanation of why I chose this specific Yudkin study, let me know, and I’ll post on it later.

This Keys/Yudkin post got Anthony Colpo agitated to the max. Why? As near as I can figure, for a couple of reasons. First, I said I thought that calories aren’t always calories in the way most people think of them. Second, because I implied that such a thing as a metabolic advantage exists. And third because in response to one of the comments I had the temerity to opine that I thought Colpo might be wrong on the metabolic advantage issue.

That’s it. That’s what has inspired all the name calling, accusations of idiocy and other foaming at the mouth that has been going on since.

It started with an open letter to me that I received by email. Here is a pdf of the letter, email and follow up that I copied from Anthony’s site. an-open-letter-to-dr-michael-eades.pdf

As you can see when you read it, Anthony is fond of using fonts to make his points. One wonders where he is going to get all the fonts he may need as this interchange ensues?

For some reason Colpo seems to have a lot of his ego tied up in being correct on the metabolic advantage. After doing what he considers his due diligence, he has decided that there is no metabolic advantage, and that anyone who says there is qualifies as a moron. Richard Feinman and Eugene Fine both believe there exists a metabolic advantage, ergo they’re morons. Same holds for Gary Taubes. Last thing I read from Anthony was that he hadn’t read Gary’s book yet, but he (Colpo) had heard that Gary refutes the calorie is a calorie idea, ergo Taubes is a moron. Same goes for me for all the same reasons. Colpo has gotten so worked up over this issue that he has actually taken the time to write a 50 page book attacking Taubes, Feinman, Fine and me. You can download your very own copy below.

Now as you read all this sturm and drang remember that what we’re talking about as a metabolic advantage is at the max about 300 kcal per day. That’s the most I’ve ever seen demonstrated in a study, so that’s probably the outside range. Calorically that represents about two frankfurters per day or a medium bagel. What that means is that if you figured out how many calories you had to eat to maintain your weight on a low-fat diet, you could consume that many very-low-carb calories plus the two frankfurters and still maintain your weight. Of course, if instead you ate the bagel, which has about the same number of kcal as the two wieners, you would lose your metabolic advantage because almost all of its calories are carbs.

So we’re not talking about a whole lot of calories here. It’s not as if I’ve written that you could eat 10,000 kcal per day and still lose weight as long as you follow a low-carb diet. I’m talking about a few hundred calories per day at best. It’s just not that big a deal. Certainly not a big enough deal to make all this fuss over.

Before I give you my thoughts on the metabolic advantage issue, I want to speak for Feinman, Fine, and Taubes, even though they haven’t asked me to.

Feinman and Fine are experts on the laws of thermodynamics, a subject on which they have published a number of papers. Recall in an earlier post of mine that of all the laws of nature, the laws of thermodynamics are the least likely to ever be overturned. Even Anthony Colpo with his self-proclaimed towering intellect hasn’t been able to defy or refute the laws of thermodynamics.

The very nature of the second law of thermodynamics implies that there has to be a metabolic advantage. Feinman and Fine published a paper stating this and discussing a number of recent papers showing that there does indeed appear to be a measurable metabolic advantage that accrues to those following a low-carb diet. Here is another Feinman/Fine paper and another in pdf. thermodynamics-and-metabolic-advantage-of-weight-loss-diets.pdf

I seriously doubt that Anthony Colpo can understand the math, biochemistry and/or the reasoning in any of these papers. But he doesn’t have to because, you see, he just knows that there isn’t a metabolic advantage, so anyone who writes a paper saying that the second law of thermodynamics virtually demands that there be one is a fool. Thus his criticism of Fine and Feinman. No substantive discussion of their work; no intelligent criticism; simply a dismissal because their work contradicts what Anthony believes with all his heart to be true.

Same with Gary Taubes. I suspect that Anthony has yet to read Gary’s book, which lays out in great detail the basis for his ideas. Colpo heard that Gary wrote that one can consume more calories on a low-carb diet than on a low-fat diet and still lose weight, which is all Anthony had to hear. It saved him from having to read that great big book because he just knows Taubes has to be an idiot to write such twaddle. Never mind that Gary researched the subject in greater depth than anyone who has ever written on it – that doesn’t matter. What matters is that after spending five plus years of his life studying the subject Gary’s conclusions contrast with Anthony’s. Therefore Gary is just another diet book author preying on the simple minded to harvest his millions.

Since this entire brouhaha stems from a difference of opinion on the existence of a metabolic advantage, let me go on the record and state my opinion.

I didn’t just wake up one morning and decide that by God there is a metabolic advantage, and that’s all there is to it. My opinion has been formed by my comprehensive reading on the subject (contrary to what Colpo thinks, he is not the only person who reads the medical literature. I was humping it to the medical library and pulling papers when Anthony was still in diapers) and my 25 plus years of medical practice taking care of overweight people. I do think that calories count. That is an unquestionable fact. But they don’t count in the way most people think they do. Let me explain.

Insulin is the primary metabolic hormone responsible for both storing fat in the fat cells and keeping it there. If your insulin levels are up, fat is on a one way street into the fat cell. And it’s pretty much trapped there until insulin levels fall, allowing fat to escape. When you go on a low-carb diet, you reduce insulin levels markedly, and you do it quickly. You put yourself into a metabolic situation in which fat can easily flow from the fat cell to the tissues where it is burned. But just because you’ve put yourself in a situation where fat can easily come out of the fat cell doesn’t necessarily mean that it will. In order for the fat to come out, you must create a caloric deficit.

If you are eating enough fat (the main macronutrient on a low-carb diet) to meet all your body’s energy needs, your fat cells have no reason to give up their fat, and they don’t. Despite the door’s being open, the fat won’t come out unless it’s needed. Even on a low-carb diet you have to create the caloric deficit to get the fat out and get it burned and lose weight. So far, it all sounds pretty Anthony Colpo-ish, but that’s about to change.

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As far as I’m concerned there are two parts to the metabolic advantage question. One that will send our good friend Anthony into a rage – another that will make him absolutely apoplectic.

First, the metabolic advantage in the context of diet is simply measured as the difference in caloric intake required to lose weight on either a low-fat or a low-carb diet. Let’s say that you closely monitor a group of subjects on a low-fat diet, and you find that as their caloric intake falls to, say, 1800 kcal per day, they begin to lose weight. Above 1800 kcal they hold steady or start to gain; below 1800 kcal they lose.

Now you start those same subjects on a low-carb diet. You find that now they start to lose weight as their intake drops below 2000 kcal and they maintain at 2000 kcal or above. This 200 kcal difference is the metabolic advantage created by the low-carb diet. In other words, on the low-carb diets these subjects can eat 200 more kcal than they can on a low-fat diet and still lose weight. The scientific literature is full of studies showing this phenomenon, so don’t let Anthony Colpo tell you it doesn’t exist. Plus the second law of thermodynamics predicts it. And looking at the biochemistry it’s easy to see why.

Basically what happens is that the body uses more energy to maintain blood sugar levels during a low-carb diet than it does during a low-fat diet. When you eat glucose or starch it hits the blood as glucose, so there isn’t really any energy expended in converting it. When you don’t eat enough carbs to provide all the glucose the body needs, the body has to make it from protein. It’s obviously more costly energy-wise to make glucose from protein than it is to use the glucose ready made. Colpo mistakenly believes this energy has already been accounted for as the thermic effect of the protein, which is higher than the thermic effect of carbohydrate or fat. The thermic effect of protein is simply the energy required to metabolize the protein normally, not that required to run it through the gluconeogenic machinery to convert it to glucose. This latter process consumes more energy.

But wait, there’s more. The increased dietary fat in a low-carb diet increases the mitochondrial density within the cells, and this fat also increases the synthesis of uncoupling proteins that dissipate energy within these mitochondria. Along those same lines data indicate that both the elevated fat and subsequent ketone formation increase the proton leak across the inner mitochondrial membrane, which dissipates even more excess energy. And this doesn’t even include the increase in futile-cycling that can go on within the mitochondria, getting rid of more.

Now the above is the part of the metabolic advantage idea that gives Anthony hives. What will really put him over the edge is what comes next.

Remember when I wrote a few paragraphs back that when insulin levels are low fat is no longer held in the fat cells? The doors to get out are wide open and fat can easily flow out – but only if there is a caloric deficit and that fat is needed to make it up. If there isn’t a deficit the fat stays where it is and there is no weight loss. There is another side to that equation. When insulin levels are low, it is extremely difficult to increase the amount of fat inside the fat cells.

Both MD and I have had patients who complained to us that they were following our program to the letter and weren’t losing any weight. When we asked them for their diet diaries we found that they were consuming huge amounts of food but were rigorously keeping their carbs below 30 grams per day. Sometimes we calculated that these patients were eating 4000+ kcal per day, which could have even been higher given that patients tend to under report what they eat instead of over reporting. What was amazing to us was that they weren’t gaining. They were pretty much maintaining their weight on an enormous number of low-carb calories.

We would explain to them about how they needed to create a caloric deficit to lose. Most people will create the caloric deficit when they go on a low-carb diet because the increased fat and protein in the absence of carbs is extremely satiating. But some folks don’t have the off switch that most others do and can eat large amounts of fat and protein along with very little carb without seeming full. You would think they would gain weight like crazy, but they don’t because with low insulin levels it’s tough to pack fat into the fat cells.

This isn’t so strange when you consider that typically the first symptom experienced by a type I diabetic is an unexplained weight loss. Many of these people go to their doctors saying that they’re eating like hogs, yet are losing weight like crazy. All it takes is a quick check of their blood sugar, which is always sky high to make the diagnosis.

These type I diabetics have no insulin so they can’t really stuff fat into their fat cells. And they are breaking protein down, converting it to glucose and urinating it away. They are voraciously hungry and eat, eat, eat but they can’t store any fat. If they go untreated they will ultimately develop severe life-threatening problems. Their fragile situation demonstrates that in the absence of insulin it’s virtually impossible to gain weight.

After following a low-carb diet for a while, our overweight patients lower their insulin levels, so, as with type I diabetics, it is difficult for them to store fat as well. They crank up all the futile cycling, elevate levels of uncoupling protein synthesis and increase proton leakage to dissipate the excess energy they’re consuming, but they don’t store it as fat. This situation creates an enormous metabolic advantage, but one that is used to maintain weight, not lose it. This is why it is pretty easy to maintain your weight loss on a low-carb maintenance diet. If you start throwing back the carbs, however, you will lose this advantage.

A number of studies have shown a metabolic advantage of the first type discussed, but the second type – the weight-maintenance type – arises from MD’s and my hands-on treatment of many patients. And from our thinking the biochemistry through. As far as I know there are no recent papers that have studied this phenomenon specifically, but a few skirt around the edges. Much of the work done by Pennington back in the 1940s and 1950s discusses the same phenomenon. And I have heard other doctors who take care of patients with low-carb diets remark on it as well.

That’s pretty much my take on the metabolic advantage. Until he reads this, Anthony won’t see the second part of my metabolic advantage beliefs, so the driving force behind all his outrage the past couple of months is over the measly couple of hundred calories that I believe exist as a metabolic advantage as a consequence of rigorously following a low-carb diet. The amount of huff he has put up over this seemed a little extreme to me, but then I started looking a little more closely at our friend Anthony, and a few things started to become clear.

Anthony is seeking the attention and publicity, which he considers his due for having written a book that few people bought.

What follows is The Anthony Colpo Reader, a few gems from Anthony’s pen to give insight into his character. (Some with my commentary) Plus the promised free book.

The following is the post that made me realize his quest for attention. I apologize for the foul language, but it’s his, not mine.

A reader of his wrote him asking why he couldn’t carry on a civil debate with me and others and why he had to resort to nastiness. This person also pointed out that he (AC) would be better received as a serious researcher were he to tone down his vitriol. Here is his answer, positively brimming with civility.

You know, I really am starting to find this all quite amusing. On one hand, folks like you claim that my style will cause me to be dismissed as some kind of nut job, but at the same time, you are all furiously typing about me on web forums.

If I am so irrelevant and such a non-entity, why do you all spend so much time talking about me?

It’s because I AM important to you. That’s not my opinion, but yours. You unwittingly reiterate this viewpoint every time you make a post about me. Obviously, what I say does indeed matter to you because otherwise you wouldn’t spend so much time writing about it. If I was the ostracized lone voice you so desperately wish to believe I am, then people wouldn’t waste their time on me. My impact would be non-existent. The truth is, my impact is very real – and that’s exactly what eats at you folks.

A lot of low-carbers thought it was great when I used to rip on the low-fat movement for all the rubbish that crowd used to spin. But when I started highlighting the equally unscientific nonsense spouted by many within the low-carb camp, then these same low-carbers started foaming at the mouth and launching repeated attacks on me.

By doing so, they have shown the world what utter hypocrites they are. Evidently, they are happy to jump all over the low-fat movement for the slightest transgression, but are happy to embrace the most absurd BS from within their own camp if it supports what they wish to believe.

Imagine if someone in the low-fat movement came out and said that we should ignore metabolic ward trials because people on low fat forums vigorously insist that they did indeed lose more weight by eating an isocaloric low-fat diet. You jokers would be dumping on their comments to no end. And yet, when people within the low-carb camp make an equally absurd claim, you have the gall to suggest they should be taken seriously!!

UNFKNBLVBL !!!

Sorry, but BS is BS, whether it comes from Ornish, Campbell, Atkins, or Eades…or from their goofball followers on low-fat and low-carb forums.

You folks are going to have to deal with the following facts:
I am right on the metabolic advantage issue.
A LOT of people from all over the world listen to me.
Like I said, what you folks really need to do is spend less time slagging off at me and a lot more time doing some serious soul searching. Why are you folks so pathetic that you will spend so much time and effort denigrating someone who tells you things you don’t want to hear – even when he has the evidence to back up his claims?

I’m sorry, but the whole “Colpo is a rude, rude man” thing is starting to wear a bit thin, it’s so transparent. With all the injustice and deceit going on in the world right now, you get upset over THIS?

Like I said, you poor bastards really need to turn your attention inwards. It will be a disturbing and unsettling experience for many of you, but you need to start sometime. It’s either that, or keep going through life with your heads up your a*sholes.

If you need to be reminded of the dire consequences that can result from such an insistence on being such easily-distracted, gullible, banality-obsessed dolts, then I suggest you watch the following movie immediately: ZEITGEIST

Another answer to a similar question about why he is so rude to people with whom he disagrees. This answer, too, shows how much he relishes the attention.

What a pack of wankers on web forums, many of whom have already demonstrated themselves to be ignorant, gossip-mongering losers, are saying is of little consequence to me. I suspect that deep down inside these jokers really value people like me because I give these losers something to gossip about and occupy their otherwise empty and meaningless lives.

Again, since this whole hoo-hah, my web hits and book sales have remained elevated.

Which means MORE people are now listening to me, and being exposed to the facts.

That’s the reality, whether you wish to believe this uncomfortable fact or not.

So, I should really thank these jokers for the increased publicity. As Oscar Wilde once said: “The Only Thing Worse than Being Talked About is Not Being Talked About”.

Pinnacle studio 9 serial key free download. And I suspect that what really gets under the skin of people like you is that I’m the one with the nads to stand up and highlight this kind of BS. What are you doing to further public health and knowledge, besides coming on to this forum and sounding like a nagging, serial whining spouse?

Here is AC’s response to a reader of his who had the temerity to ask a few reasonable questions. Admittedly there are more than a few typos here, but the questions are pretty clear. And very reasonable.

Question: I have two basic questions –can you give a response to the “metabolic ward study” that muscular develpoment [Muscular Development – a body building magazine] cites—?? and can you explain how one can gain fat if unsulin levels are low (lowering ones carbs means insulin levels will be low)—can you also adress the fact that people with type 1 diabeties lose weight rapidly because they produce little or no insulin??? There are no insults here just questions—an what is the big deal–if you are correct then you should welcome this debate…

Uh oh. AC is pulling out the fonts again. It must be bad.

I don’t know how many times I have to repeat myself, but here goes again:

YOU ARE, BEYOND ANY SHADOW OF A DOUBT, A DERANGED F*CKWIT. Your behavior on this forum has been appalling. You are NOT welcome here and I WILL NOT BE ANSWERING ANY OF YOUR QUESTIONS. I DO NOT WASTE MY TIME ANSWERING QUESTIONS NOR GIVING FREE ADVICE TO A**HOLES WHO DEMONSTRATE MALEVOLENT INTENT TOWARDS ME, AS YOU HAVE.

I am nice to those who are nice to me, I have no time whatsoever for those who behave like a*sholes towards me. Quite simple really, although I have no doubt that such a straightforward concept is beyond the comprehension of a little peanut like yourself.

Everything I have to say about the fat loss/metabolic ward study issue is in my book, The Fat Loss Bible. If you were to get off your fat lazy ass and read it, all your stupid questions would be redundant. If you choose not to read the book, then do not expect me to give of my time discussing issues that are addressed in the book.

BTW, YOU LITTLE WEASEL…if you live in, or ever visit, Australia, be sure to forward me your full name and location so we can arrange a little one-on-one ‘meeting’ to see who really is the coward.

FFS, move out of your Mum’s home, get a job, throw away your gay porn collection, and get a goddamn life…you little bed-wetting pissant…

Charming.

Finally, here is the link to Anthony’s piteous whine about why he took down his TheOmnivore website and replaced it with an advertorial for his book. I will post this as a link because it is on another website, and I don’t think AC can take it down at will. If he does, fear not, I have a pdf copy that I’ll put up.

It seems that AC got miffed because he put a lot of time and effort into his website figuring that it would lead people to buy his book. But they didn’t. At least not in the quantities he expected. So he took the website down, picked up his toys and went home.

At the end of this sniveling dreck AC writes the following words.

I am also working on a fat loss book that will once and for all address the unrepentant stupidity of people who think that eating high/low-fat/carbs/protein at the same caloric intake awards some sort of magical weight loss advantage.

And, folks, Anthony is a good as his word. He has written an ebook titled The Fat Loss Bible doing that very thing – addressing the unrepentant stupidity of people like me. (More about this book in a moment)

But he didn’t stop there. AC is so convinced of his righteousness that he buckled down and wrote another book attacking not just unrepentantly stupid people like me, but actually attacking me personally along with Feinman, Fine and Taubes. My unrepentant stupidity has earned me an entire chapter of my own, replete with color picture. And best of all, AC is not selling this book, he is giving it away. He has made it available for me to give to all the readers of my blog absolutely free of charge. Download your free book in pdf right here compliments of Anthony Colpo. they_are_all_mad.pdf

Now, about The Fat Loss Bible…

You can get a harbinger of things to come by simply reading the Acknowledgments. I won’t bore you with the whole thing, but just a taste here and there.

AC decides to “part with tradition” and instead of thanking those who helped him he thanks those who attacked him. He wants to

acknowledge a group of people who attacked me in late 2005 after I wrote an Internet article explaining why caloric intake – not the proportion of protein, carbohydrate or fat – is the primary determinant of weight loss.

Low-carbohydrate devotees the world over were outraged at my temerity to state this indisputable fact. I was demonized on Internet forums, and accused of lying.

…[Yada yada yada yada. More of the same. If you’ve read much AC, you get the picture.]…

The staggering level of willful ignorance displayed by my detractors in 2005 impressed upon me the urgent need for a book explaining the true scientific facts about weight loss. Clearly, a lot of people had been brainwashed by gimmicky nonsense.

I suspect the book has come too late for my venomous critics of 2005. I have to seriously question whether those who unfairly slandered my integrity, who ignored the evidence I presented, and who chastised me for daring to present the facts that allegedly harmed their pet ’cause’ possess any real sense of logic or reason. But regardless of whether it will help them, by inspiring the creation of this book, their actions will indirectly benefit thousands of others…

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One wonders how many of these ruthless attackers there were out there slandering, ignoring and chastising? A half dozen maybe? This guy is truly a legend in his own mind.

To give him credit, though, he does write one worthwhile paragraph in this two page whine when he discusses a common facet of human nature.

Namely, many people really don’t care for the truth. They are more concerned with reinforcing what they have already come to accept as true. It takes a certain strength of character to discard long-cherished beliefs. Sadly, many people simply cannot muster the requisite strength of character, even when the evidence is overwhelming.

Sadly, I suspect AC is one of those people.

I have read The Fat Loss Bible and I can summarize it in one sentence: Eat less, exercise more, and you’ll lose weight. Of course that message is buried in with all the typical AC folderol about how smart he is and how ignorant everyone else is. If you want to spend $40 to be told to eat less and exercise more while learning what a misunderstood and viciously slander genius AC is, then The Fat Loss Bible is the book for you.

The first chapter lays out the basis for AC’s belief that there is no metabolic advantage. It is a compendium of misread or misinterpreted studies, the famous “NINETEEN metabolic ward studies” AC mentions in his open letter to me. (There were only SEVENTEEN in the version of the book I read, but who’s counting?)

Here is what I propose to do. Since this chapter of this book is the foundation for AC’s bedrock belief in the non-existence of a metabolic advantage, I will go through it and in meticulous detail demonstrate just what a shaky foundation that is. But I will do it only if you – the readers of this blog – want me to. It will take a little time that could otherwise be spent in posting on the stuff I usually post on. You can vote with your comments. I’m not going to respond to any of these comments, but I will put them up and tally them. If the yeas outnumber the nays, I’ll do the critique.

My only worry is that AC is a pretty slippery fellow. One of the readers on his site asked why AC didn’t publish his book as a real, bound book instead of an ebook. AC responded that with the ebook he could change it at will and continue to add new material. Chapter One has gone from the 20 pages it was when I first looked at this book back in late August to 26 pages when I pulled it down a few days ago. So I may be trying to hit a moving target. But I do have a copy of the book as it exists right now and that’s what I will critique if the votes send me in that direction. If, for whatever bizarre reason, you happen to decide to drop forty bucks later on to purchase this book, you may find you bought a different book than the one I’ll dismember.

So, as they say in Chicago: vote early and vote often. Meanwhile I’ll be off dealing with all the comments that have been stacking up while this post was being written.

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